Profile of King-Wai Yau.

In vivo gene delivery in the retina using polyethylenimine.

Phototransduction Motifs and Variations

Seeing begins in the photoreceptors, where light is absorbed and signaled to the nervous system. Throughout the animal kingdom, photoreceptors are diverse in design and purpose. Nonetheless, phototransduction-the mechanism by which absorbed photons are converted into an electrical response-is highly conserved and based almost exclusively on a single class of photoproteins, the opsins. In this R...

Elementary response of olfactory receptor neurons to odorants.

Signaling by heterotrimeric GTP-binding proteins (G proteins) drives numerous cellular processes. The number of G protein molecules activated by a single membrane receptor is a determinant of signal amplification, although in most cases this parameter remains unknown. In retinal rod photoreceptors, a long-lived photoisomerized rhodopsin molecule activates many G protein molecules (transducins),...

Interskeletal Variation of Bone Mineral Density, Geometry and Microstructure in Long Bone Shafts under Habitual Loading

Interskeletal Variation of Bone Mineral Density, Geometry and Microstructure in Long Bone Shafts under Habitual Loading Yau Ming Lai1, Ling Qin2, Kwong Man Lee2, Chun Wai Chan2, Kai Ming Chan2 1Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China; 2Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, Chin...

Identification of Ligands for Olfactory Receptors by Functional Expression of a Receptor Library

The recognition of odorants by olfactory receptors represents the first stage in odor discrimination. Here, we report the generation of an expression library containing a large and diverse repertoire of mouse olfactory receptor sequences in the transmembrane II-VII region. From this library, 80 chimeric receptors were tested against 26 odorants after transfection into HEK-293 cells. Three recep...